What are the major reasons why patients fail to respond to TKI therapies?

Patient FAQs published on October 9, 2015
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What are the major reasons why patients fail to respond to TKI therapies?
The medications that you are taking for your chronic myeloid leukemia usually work and most patients will do well, but occasionally some patients may not respond. What can you do to improve your chance of response? Take your medications. Nonadherence, not taking the medication, is the main reason why some patients do not do well. Sometimes, patients are put on other medicines like antacids that inhibit the ability of your tyrosine kinase inhibitor or your CML medication to work, so if you start a new medication, bring that to your cancer doctor’s attention, and then sometimes unfortunately the disease gets nastier. The doctor can determine this by doing what is called a mutation study.

MediCom Worldwide, Inc. acknowledges the collaborative support from The Leukemia & Lymphoma Society (LLS).

Additional Resources
www.LLS.org/CML - CML webpage with links to resources
www.LLS.org/booklets - Chronic Myeloid Leukemia (booklet) and Chronic Myeloid Leukemia Guide(easier to read booklet)
www.LLS.org/PCR - Financial Assistance for PCR test
www.LLS.org/educationvideos - Two videos - CML: The Role of PCR Testing and Resistant Myeloid Leukemia
www.myPCR.org - Coalition of CML-focused organizations provides information about PCR, campaign to increase awareness of the need to monitor CML treatment, and resources for patients.

Last modified: April 4, 2016